The development and use of bulk resources are essential for industrial systems. However, current resource use patterns are unsustainable, with low efficiency and high carbon emissions. The study “Integrated optimization modelling framework for low-carbon and green regional transitions through resource-based industrial symbiosis” introduces a quantitative tool for resource-based industries to promote sustainable and low-carbon transitions in regional economies. The Qinghai Lake region, known for its salinity, was used as a case study to assess this tool’s effectiveness. Optimizing the industrial structure resulted in benefits such as increased economic output, better resource efficiency, reduced energy consumption, less solid waste, and lower carbon emissions. Scenario analyses showed that optimal development paths significantly outperform traditional ones in terms of carbon reduction, economic output, and resource efficiency. This highlights the urgent need for cleaner technology and industrial symbiosis in regional industries.
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